Nuendo certainly seems to be impressive, although my 2.0 version doesn't
want to see my Digi9652 even though Samplitude 7.23
does.

For the 9652, the most up-to-date drivers are on the RME site:

http://www.rme-audio.com/english/index.htm

You might also check in on the forums at www.nuendo.com; if you can wade
through all the juvenalia, platform-bashing and colorful international didn't
rtfm nonsense there's a lot of good information on there-- also the associated
info base.

There are lots of 9652 users there... I'm one of them, but on a Mac.

Happy new year,

MC