"Go to www.audioquest.com., click "Cable Theory", and read
page 5. Among the many gems of knowledge provided the

snip

"Since human perception is more aware of the existence of a distortion
than the quantity, the better the cable, the worse in some ways it will
sound when new, because the anemic forced two-dimensional effect
reulting from being new will not be ameliorated by other gentler
distortions."

"While cable directionality is not fully understood, it is clear that
the molecular structure of drawn metal is not symmetrical, providing a
physical explanation for the existence of directionality.""

A few years ago in speaker coil mag., belden wire reported a test where
wire whose directiondrawn was known to see if people could identify it
when two samples of the same wire were was used and one was reversed,
blinding was not required because there was no external sign of
"direction". No difference could be detected.